Cell autonomous inflammation in VEXAS is mediated by cGAS-STING
Samuel J. Magaziner, Jason C. Collins, Brecca Miller, Patrick Zheng, Amy K. Wang, Jérôme Hadjadj, Juan Carlos Balandrán, Maria Sirenko, Maya English, James Bertlin, Rebecca L. Murray, Peter H. Whitney, Tania J González-Robles, Deborah Rivera, Yan Wang, , David B. Beck
This study identifies cGAS-STING pathway activation as a key mechanism of inflammation in VEXAS, showing that UBA1 mutations disrupt ERAD and mitochondrial homeostasis, leading to STING-driven inflammation.
bioRxiv · May 29, 2026 · PreprintGenetics