Jason C. Collins

Cell autonomous inflammation in VEXAS is mediated by cGAS-STING

This study identifies cGAS-STING pathway activation as a key mechanism of inflammation in VEXAS, showing that UBA1 mutations disrupt ERAD and mitochondrial homeostasis, leading to STING-driven inflammation.

A tissue-specific ubiquitin switch coordinates brain, craniofacial, and skin development

The paper identifies a ubiquitin switch mechanism that regulates CDC42 signaling to coordinate ectodermal patterning in vertebrate development.

A kinase-dependent checkpoint prevents escape of immature ribosomes into the translating pool

The paper identifies a kinase-dependent checkpoint involving Rio1, Nob1, and Pno1 that prevents immature ribosomes from entering the translating pool, ensuring proper maturation and preventing fidelity defects.