Author

Manisha Singh

The University of Texas MD Anderson Cancer CenterORCID 0000-0003-1983-4921Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:deconvolution· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:spatial transcriptomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Scott KopetziD· 2 shared Akash R. BodaiD· 1 shared Ansam F. SinjabiD· 1 shared Caner ErcaniD· 1 shared Dev GoheliD· 1 shared Fuduan PengiD· 1 shared George A. CăliniD· 1 shared Hao Yan· 1 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBioinformatics

Scott KopetzORCID

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3 papers

Recent·Most cited

BioinformaticsbioRxivPreprintNov 21, 2025

Deconvolution of Sparse-count RNA Sequencing Data for Tumor Cells Using Embedded Negative Binomial Distributions

Matthew D. Montierth, Hao Yan, Liyang Xie…·Wenyi Wang

The paper develops DeMixNB, a deconvolution model for sparse-count RNA sequencing data, showing its utility in analyzing tumor cell plasticity in breast and lung cancer.

DOI 10.1101/2025.11.21.689822

humanbulk RNA-seq

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Cancer BiologybioRxivPreprintFeb 23, 2025

IL-1R1 Blockade Enhances CD40 Agonist-Mediated Immune Responses but Fails to Increase Efficacy or Mitigate Hepatotoxicity in Pancreatic Cancer

Akash R. Boda, Irfan N. Bandey, Saikat Chowdhury…·Manisha Singh

This study investigates the effect of IL-1R1 blockade on CD40 agonist therapy in PDAC, finding it does not improve efficacy and worsens liver toxicity.

1 citation

mouseexperimental assay

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GeneticsbioRxivPreprintAug 28, 2021

Vectofusin-1 based T-cell transduction approach for generating murine chimeric antigen receptor T-cells for cancer.

Romil D. Patel, Kartik Devashish, Shubhra Singh…·Neeraj Y. Saini

This study evaluates vectofusin-1 as a transduction enhancer for generating murine CAR-T cells, finding it comparable to Retronectin.

DOI 10.1101/2021.08.28.458011

mouseexperimental assay

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