Sandrine Da Cruz

SubCellSpace identifies and characterizes subcellular mRNA localization patterns in spatial transcriptomics data using a computational framework.

The paper creates a single-nucleus transcriptomic atlas of oligodendrocytes in ALS, identifying disease-associated activation states and potential biomarkers.

This study shows that injecting human FUS fibrils into mice with human FUS causes FUS aggregation and FTLD-like disease progression, with prion-like spread and cognitive deficits.

This study shows that wild-type FUS rescues ALS-like disease caused by mutant FUS by activating an autoregulatory loop that reduces cytoplasmic mutant FUS levels.