Frances Rocamora

Glycoengineered recombinant alpha1-antitrypsin results in comparable in vitro and in vivo activities to human plasma-derived protein

This study generates glycoengineered recombinant alpha1-antitrypsin with in vitro and in vivo activities comparable to plasma-derived A1AT, offering a sustainable therapeutic alternative.

Systematic Mapping of Protein Interactions Underlying IL-2 Secretion in Human T Cells

The paper maps protein interactions involved in IL-2 secretion in human T cells, identifying key components of the secretory pathway and their dynamic regulation.

LeGenD: determining N-glycoprofiles using an explainable AI-leveraged model with lectin profiling

LeGenD predicts N-glycan structures and their abundance using lectin-binding patterns and AI, trained on glycoprofiles from recombinant proteins.

Improving Recombinant Antibody Production Using FcBAR: An In Situ Approach to Detect and Amplify Protein-Protein Interactions

The paper introduces FcBAR, a method to detect protein-protein interactions in situ for recombinant proteins, and identifies factors that enhance rituximab production.

Enhanced Production of HCV E1E2 Subunit Vaccine Candidates via Protein-Protein Interaction Identification in Glycoengineered CHO cells

The paper identifies protein interactors that enhance the secretion of HCV E1E2 vaccine candidates in glycoengineered CHO cells using a multi-omics approach.

Antagonistic roles of NOT1 paralogues in the timing of gene expression in Plasmodium falciparum

This study shows that two NOT1 paralogues in Plasmodium falciparum have opposing roles in regulating mRNA abundance during the intraerythrocytic developmental cycle.