Author

Adrien Grimont

Weill Cornell MedicineORCID 0000-0003-1998-580XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Assay:DNA methylation· 1 Organism:human· 1 Organism:mouse· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Rohit ChandwaniiD· 2 shared Steven D. LeachiD· 2 shared Alexa OsterhoudtiD· 1 shared André F. RendeiroiD· 1 shared Anil K. Rustgi· 1 shared Aslihan YavasiD· 1 shared Christina S. LeslieiD· 1 shared Christine A. Iacobuzio–DonahueiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCancer Biology

Rohit ChandwaniORCID

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2 papers

Recent·Most cited

Cancer BiologyDevelopmental CellPeer-reviewedJul 21, 2026

Molecular dynamics driving phenotypic divergence among KRAS mutants in pancreatic tumorigenesis

Adrien Grimont, David J. Falvo, Whitney J. Sisso…·Rohit Chandwani

This study investigates how different KRAS mutations drive distinct phenotypic outcomes in pancreatic tumorigenesis, revealing mutation-specific oncogenic pathways and therapeutic implications.

3 citationstop 3%

mouseexperimental assay

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Cancer BiologybioRxivPreprintMar 11, 2026

A Genetically Engineered Human Organoid Model Reveals Distinct Genetic and Epigenetic Barriers of Lineage Plasticity in Early PDAC Transformation

X Zhang, W. Douglas Wong, Hyunwoo Cho…·Danwei Huangfu

This paper develops a human organoid model of early PDAC that identifies genetic and epigenetic barriers to lineage plasticity, showing CDKN2A loss is essential with KRAS/TP53 mutations and TET1 suppression links ERK signaling to transcription factor silencing.

DOI 10.64898/2026.03.09.710586

humanscRNA-seq

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