Author

Steven D. Leach

Dartmouth CollegeORCID 0000-0002-2689-1871Unclaimed ORCID profile · follow to get notified of new preprints

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Steven D. Leach1 paper

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Assay:DNA methylation· 1 Organism:human· 1 Organism:mouse· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Adrien GrimontiD· 2 shared Rohit ChandwaniiD· 2 shared Alexa OsterhoudtiD· 1 shared André F. RendeiroiD· 1 shared Anil K. Rustgi· 1 shared Aslihan YavasiD· 1 shared Christina S. LeslieiD· 1 shared Christine A. Iacobuzio–DonahueiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCancer Biology

Adrien GrimontORCID

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2 papers

Recent·Most cited

Molecular dynamics driving phenotypic divergence among KRAS mutants in pancreatic tumorigenesis

Adrien Grimont, David J. Falvo, Whitney J. Sisso, Francisco dos Santos, Christopher W. Chan, Paul Zumbo, William B. Fall, Katherine R. Ferrick, Grace Pan, Megan Cleveland, Tomer M. Yaron, Alexa Osterhoudt, Yinuo Meng, María Paz Zafra, André F. Rendeiro, , Rohit Chandwani

This study investigates how different KRAS mutations drive distinct phenotypic outcomes in pancreatic tumorigenesis, revealing mutation-specific oncogenic pathways and therapeutic implications.

Developmental Cell · Jul 21, 2026Peer-reviewedCancer Biology

A Genetically Engineered Human Organoid Model Reveals Distinct Genetic and Epigenetic Barriers of Lineage Plasticity in Early PDAC Transformation

X Zhang, W. Douglas Wong, Hyunwoo Cho, Dapeng Yang, Gary Dixon, Renhe Luo, Dingyu Liu, Denis Torre, Shigeaki Umeda, Federico Gonzãlez, Gökçe Aşkan, Aslihan Yavas, Jeyaram Ravichandran Damodaran, Robert W. Rickert, Rajya L. Kappagantula, , Danwei Huangfu

This paper develops a human organoid model of early PDAC that identifies genetic and epigenetic barriers to lineage plasticity, showing CDKN2A loss is essential with KRAS/TP53 mutations and TET1 suppression links ERK signaling to transcription factor silencing.

bioRxiv · Mar 11, 2026 · PreprintCancer Biology