Author

Joseph S. Pak

University of ChicagoORCID 0000-0003-2004-9015Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:C. elegans· 2 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Assay:proteomics· 2 Organism:human· 1 Research Focus:protein design· 1

Frequent Co-Authors

Brock J. GrilliD· 2 shared Engin ÖzkaniD· 2 shared Joseph W. ThorntoniD· 2 shared Karla J. OppermaniD· 2 shared Yeonwoo ParkiD· 2 shared A. JaworskiiD· 1 shared Charu KapiliD· 1 shared Christina Roman· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersNeuroscience

Brock J. GrillORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Evolution of NELL binding by dual-ligand-responsive axon guidance receptor Robo

Joseph S. Pak, Lakshmi Prakash, Yeonwoo Park, Wioletta I. Nawrocka, Raunak Kundagrami, Joseph W. Thornton, A. Jaworski, Engin Özkan

The paper investigates the evolutionary origin of NELL-Robo interactions and shows that dual-ligand responsiveness is conserved in chordates but not protostomes.

bioRxiv · Sep 24, 2026 · PreprintBiochemistry

UBR-1 enzyme network regulates glutamate homeostasis to affect organismal behavior and developmental viability

Joseph S. Pak, Seamus R. Morrone, Karla J. Opperman, Mukul Kumar Midha, Charu Kapil, Neal D. Mathew, Damon T. Page, Ning Zheng, Robert L. Moritz, Brock J. Grill

This study identifies UBR-1 as a hub regulating glutamate homeostasis through a signaling axis, affecting locomotion and developmental viability in C. elegans.

bioRxiv · Jul 28, 2025 · PreprintNeuroscience

Axon development is regulated at genetic and proteomic interfaces between the integrin adhesome and the RPM-1 ubiquitin ligase signaling hub

Jonathan Amezquita, Muriel Desbois, Karla J. Opperman, Joseph S. Pak, Elyse L. Christensen, Nikki T. Nguyen, Karen Diaz-Garcia, Melissa A. Borgen, Brock J. Grill

The paper identifies genetic and proteomic interactions between the integrin adhesome and the RPM-1 ubiquitin ligase signaling hub in C. elegans neurons, showing their role in axon development and neurodevelopmental disorders.

bioRxiv · Nov 15, 2023 · PreprintNeuroscience

Molecular and Structural Basis of Olfactory Sensory Neuron Coalescence by Kirrel Receptors

Jing Wang, Neelima Vaddadi, Joseph S. Pak, Yeonwoo Park, Sabrina Quilez, Christina Roman, Émilie Dumontier, Joseph W. Thornton, Jean‐François Cloutier, Engin Özkan

This study presents crystal structures of Kirrel receptors, showing their homodimerization mechanism and its role in axon coalescence into glomeruli in the mouse olfactory system.

Cell Reports · Nov 1, 2021Peer-reviewedNeuroscience