Author

Jaime Imitola

UConn HealthORCID 0000-0003-2008-3133Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1

Frequent Co-Authors

Ethan W. HollingsworthiD· 2 shared Abbie M. Maguire· 1 shared Alfredo Quiñones‐HinojosaiD· 1 shared Annalisa M. Hartlaub· 1 shared Brian Yoon· 1 shared Calvin S. LeungiD· 1 shared Ece Dilber Gamsiz UzuniD· 1 shared Fumihiro WatanabeiD· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersNeuroscience

Ethan W. HollingsworthORCID

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2 papers

Recent·Most cited

Patient-Derived Organoids Recapitulate Intrinsic Immune Landscapes and Progenitor Populations of Glioblastoma.

Fumihiro Watanabe, Ethan W. Hollingsworth, Jenna M. Bartley, Lauren Wisehart, Rahil Desai, Annalisa M. Hartlaub, Mark E. Hester, Paula V. Schiapparelli, Alfredo Quiñones‐Hinojosa, Jaime Imitola

The paper characterizes GSC-derived GBM organoids, revealing an immune-like molecular program and identifying SATB2+ and HOPX+ progenitor populations that contribute to GBM progression.

PNAS Nexus · Feb 1, 2024Peer-reviewedNeuroscience

Dysregulation of The Chromatin Environment Leads to Differential Alternative Splicing as A Mechanism Of Disease In a Human Model of Autism Spectrum Disorders

Calvin S. Leung, Shoshana J. Rosenzweig, Brian Yoon, Nicholas A. Marinelli, Ethan W. Hollingsworth, Abbie M. Maguire, Mara H. Cowen, Michael Schmidt, Jaime Imitola, Ece Dilber Gamsiz Uzun, Sofia B. Lizarraga

This study shows that VPA exposure alters chromatin environment, leading to changes in alternative splicing and gene expression in human cortical neurons, which may contribute to ASD pathogenesis.

Human Molecular Genetics · Jan 9, 2023Peer-reviewedNeuroscience