Author

Mark E. Hester

Nationwide Children's HospitalORCID 0000-0002-3726-4128Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Research Focus:variant calling· 2

Frequent Co-Authors

Sriram VaidyanathaniD· 2 shared Afrooz RashnonejadiD· 1 shared Alfredo Quiñones‐HinojosaiD· 1 shared Allison M. BradburyiD· 1 shared Annalisa M. Hartlaub· 1 shared Aparna VenugopalaniD· 1 shared Ben Kelly· 1 shared Burçak ÖzeşiD· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersGenetics

Sriram VaidyanathanORCID

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Author profile →

4 papers

Recent·Most cited

GeneticsbioRxivPreprintMay 29, 2025

REMEDY: REpair of heterozygous Mutations independent of Exogenous Donor template with high efficiency using allele specific CRISPR targeting and HDR enhancers

Yasemin Sezgin, Genesis Snyder, Noushin Saljoughian…·Meisam Naeimi Kararoudi

REMEDY enables efficient repair of heterozygous mutations in human and mouse cells without exogenous donor DNA by using CRISPR-induced DSBs and HDR enhancers.

DOI 10.1101/2025.05.29.641201

humanmouse

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Molecular BiologybioRxivPreprintFeb 1, 2024

Single-Stranded DNA with Internal Base Modifications Mediates Highly Efficient Gene Insertion in Primary Cells

Karen L Kanke, Rachael E. Rayner, Eli Abel…·Sriram Vaidyanathan

The paper demonstrates that chemically modified ssDNA (eDNA) significantly improves gene insertion efficiency in primary cells compared to unmodified ssDNA, achieving therapeutic levels in clinically relevant loci.

1 citation

humanCRISPR screen

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NeurosciencePNAS NexusPeer-reviewedFeb 1, 2024

Patient-Derived Organoids Recapitulate Intrinsic Immune Landscapes and Progenitor Populations of Glioblastoma.

Fumihiro Watanabe, Ethan W. Hollingsworth, Jenna M. Bartley…·Jaime Imitola

The paper characterizes GSC-derived GBM organoids, revealing an immune-like molecular program and identifying SATB2+ and HOPX+ progenitor populations that contribute to GBM progression.

24 citationstop 3%

humanbulk RNA-seq

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NeuroscienceActa Neuropathologica CommunicationsPeer-reviewedDec 21, 2022

Spatially resolved transcriptomics reveals unique gene signatures associated with human temporal cortical architecture and Alzheimer's pathology

Shuo Chen, Yuzhou Chang, Liangping Li…·Hongjun Fu

This study uses spatial transcriptomics to identify gene signatures in the human temporal cortex linked to Alzheimer's pathology.

143 citationstop 1%

humanspatial transcriptomics

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