Timothy Sterne-Weiler

The paper uses isoform-specific single-cell Perturb-Seq to show that alternative promoters drive distinct transcriptional programs and affect drug response in breast cancer.

This study introduces scTaILoR-seq, a long-read targeted RNA sequencing method, to enhance single-cell transcriptome analysis and identify isoform variation and SNV associations in ovarian cancer.

Isosceles improves isoform detection and quantification accuracy in single-cell and bulk RNA-seq data using nanopore long-reads.

Whippet efficiently detects and quantifies alternative splicing, revealing extensive transcriptomic complexity and higher prevalence in tumors.