Author

Jake W. Carrasquillo Rodríguez

Yale UniversityORCID 0000-0003-2038-6329Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

Michael V. AirolaiD· 2 shared Shirin BahmanyariD· 2 shared Shujuan GaoiD· 2 shared Onyedikachi Uche· 1 shared Shoken LeeiD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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2 shared papersCell Biology

Michael V. AirolaORCID

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2 papers

Recent·Most cited

Cell BiologyMolecular Biology of the CellPeer-reviewedMay 22, 2024

Differential reliance of CTD-nuclear envelope phosphatase 1 on its regulatory subunit in ER lipid synthesis and storage

Jake W. Carrasquillo Rodríguez, Onyedikachi Uche, Shujuan Gao…·Shirin Bahmanyar

This study shows that CTDNEP1's regulatory subunit NEP1R1 controls its degradation to regulate ER membrane synthesis via lipin 1, but not lipid droplet biogenesis.

10 citations

mouseproteomics

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BiochemistryProceedings of the National Academy of SciencesPeer-reviewedMay 22, 2024

Structure and mechanism of the human CTDNEP1-NEP1R1 membrane protein phosphatase complex necessary to maintain ER membrane morphology

Shujuan Gao, Jake W. Carrasquillo Rodríguez, Shirin Bahmanyar, Michael V. Airola

This study identifies CTDNEP1-NEP1R1 as a conserved membrane phosphatase complex that restricts ER expansion, with NEP1R1 activating CTDNEP1 through structural stabilization and substrate orientation.

10 citations

humanstructural biology

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