Michael V. Airola

This study identifies a conserved NirD domain that mediates Nir1-Nir2 heterodimerization, enhancing PIP2 replenishment and expanding the dynamic range of the phosphatidylinositol cycle.

This study identifies nSMase2 as a metabolic tumor suppressor in breast cancer by restraining TAZ and inhibiting tumorigenesis.

This study presents five high-resolution structures of CpgD, revealing van der Waals interactions mediate its enantiomeric substrate preference for 2-phospho-D-glycerate.

This paper identifies DDHD2 as a neutral lipid lipase and transacylase that remodels triglyceride acyl chains by transferring acyl groups between lipids.

The paper presents high-resolution structures of Tt Pah2 in different catalytic states, revealing a conserved Asp-Arg motif critical for substrate recognition and catalysis.

The paper develops PILS-Nir1, a phosphatidic acid biosensor, and shows it detects PA dynamics in live cells with higher sensitivity than existing tools.

This study identifies CTDNEP1-NEP1R1 as a conserved membrane phosphatase complex that restricts ER expansion, with NEP1R1 activating CTDNEP1 through structural stabilization and substrate orientation.