Author

Samantha J. Walker

Wellcome Sanger InstituteORCID 0009-0006-9002-5966Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:CRISPR screen· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Cansu DinçeriD· 2 shared Emre KarakoçiD· 2 shared Gabriele PiccoiD· 2 shared Katrina McCarteniD· 2 shared Mamta SharmaiD· 2 shared Mathew J. GarnettiD· 2 shared Matthew A. CoelhoiD· 2 shared Alex Watterson· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersGenomics

Cansu DinçerORCID

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2 papers

Recent·Most cited

GenomicsbioRxivPreprintSep 14, 2026

Structure-function analysis of PI3K signalling cascade base editing screens in cancer cells

Katrina McCarten, Barbara Abreu, Benoît Baillif…·Mathew J. Garnett

The paper uses CRISPR base editing and structural analysis to identify functional residues in the PI3K pathway, revealing potential drug targets and allosteric pockets.

DOI 10.64898/2026.09.08.748517

humanCRISPR screen

𝕏 PostBluesky

Cancer BiologybioRxivPreprintDec 27, 2025

On-target mutations confer resistance to WRN helicase inhibitors in Microsatellite Unstable Cancer Cells.

Gabriele Picco, Yanhua Rao, Angham Al Saedi…·Mathew J. Garnett

This study identifies on-target WRN mutations as resistance mechanisms in MSI cancer cells to WRN helicase inhibitors and suggests combination therapies to prevent resistance.

3 citations

humanwhole-exome sequencing

𝕏 PostBluesky