Author

Merlin Crossley

UNSW SydneyORCID 0000-0003-2057-3642Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:differential expression· 2 Assay:ATAC-seq· 1 Assay:ChIP-seq· 1 Research Focus:gene regulatory network inference· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Gerd A. BlobeliD· 2 shared Lana C. LyiD· 2 shared Ren ReniD· 2 shared Xianjiang LaniD· 2 shared Xiaodong ChengiD· 2 shared Alok SrivastavaiD· 1 shared Anila GeorgeiD· 1 shared Aswin Anand PaiiD· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersMolecular Biology

Gerd A. BlobelORCID

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3 papers

Recent·Most cited

Molecular BiologybioRxivPreprintFeb 24, 2024

Mechanistic dissection of the CHD4 enhancers reveals cooperative functions among the homotypic ZNF410 clustered motifs

Siyuan Xu, Ren Ren, Chuxuan Peng…·Xianjiang Lan

The paper investigates how ZNF410 regulates the CHD4 gene through enhancer regions, showing additive contributions from two enhancers and cooperative binding of ZNF410 to clustered motifs.

DOI 10.1101/2024.02.24.581901

humanChIP-seq

𝕏 PostBluesky

GenomicseLifePeer-reviewedFeb 11, 2022

Identification of novel HPFH-like mutations by CRISPR base editing that elevates the expression of fetal hemoglobin

Nithin Sam Ravi, Beeke Wienert, Stacia K. Wyman…·Kumarasamypet Murugesan Mohankumar

This study uses CRISPR base editing to identify novel mutations in the HBG promoter that increase fetal hemoglobin expression without harmful effects.

71 citationstop 1%

humanexperimental assay

𝕏 PostBluesky

Molecular BiologyBloodPeer-reviewedNov 4, 2020

ZNF410 uniquely activates the NuRD component CHD4 to silence fetal hemoglobin expression

Xianjiang Lan, Ren Ren, Ruopeng Feng…·Gerd A. Blobel

The paper identifies ZNF410 as a highly specific transcriptional activator in erythroid cells that regulates CHD4 and fetal hemoglobin expression.

2 citations

humanexperimental assay

𝕏 PostBluesky