Author

Ren Ren

The University of Texas MD Anderson Cancer CenterORCID 0000-0001-8288-8012Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Ren Ren1 paper · The University of Texas MD Anderson Cancer Center

Biology Disciplines

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Molecular Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:differential expression· 2 Assay:ATAC-seq· 1 Organism:bacteria (other)· 1 Assay:ChIP-seq· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Xiaodong ChengiD· 3 shared Gerd A. BlobeliD· 2 shared John R. HortoniD· 2 shared Lana C. LyiD· 2 shared Merlin CrossleyiD· 2 shared Xianjiang LaniD· 2 shared Abhinav K. JainiD· 1 shared Antonello MaiiD· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersMolecular Biology

Xiaodong ChengORCID

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3 papers

Recent·Most cited

Quinoline-based compounds can inhibit diverse enzymes that act on DNA

Jujun Zhou, Qin Chen, Ren Ren, Jie Yang, Bigang Liu, John R. Horton, Caleb Chang, Chuxuan Li, Leora Maksoud, Yifei Yang, Dante Rotili, Abhinav K. Jain, Xing Zhang, Robert Blumenthal, Taiping Chen, , Xiaodong Cheng

This study identifies quinoline-based compounds that inhibit DNA methyltransferases and other DNA-targeting enzymes, with compound 11 inducing DNA damage response in cancer cells.

Cell chemical biology · Oct 21, 2024Peer-reviewedMolecular Biology

Mechanistic dissection of the CHD4 enhancers reveals cooperative functions among the homotypic ZNF410 clustered motifs

Siyuan Xu, Ren Ren, Chuxuan Peng, Haowen Lu, Lana C. Ly, Merlin Crossley, Bin Xu, Xiaodong Cheng, Gerd A. Blobel, Xianjiang Lan

The paper investigates how ZNF410 regulates the CHD4 gene through enhancer regions, showing additive contributions from two enhancers and cooperative binding of ZNF410 to clustered motifs.

bioRxiv · Feb 24, 2024 · PreprintMolecular Biology

ZNF410 uniquely activates the NuRD component CHD4 to silence fetal hemoglobin expression

Xianjiang Lan, Ren Ren, Ruopeng Feng, Lana C. Ly, Yemin Lan, Zhe Zhang, Nicholas G. Aboreden, Kunhua Qin, John R. Horton, Jeremy D. Grevet, Thiyagaraj Mayuranathan, Osheiza Y. Abdulmalik, Cheryl A. Keller, Belinda M. Giardine, Ross C. Hardison, , Gerd A. Blobel

The paper identifies ZNF410 as a highly specific transcriptional activator in erythroid cells that regulates CHD4 and fetal hemoglobin expression.

Blood · Nov 4, 2020Peer-reviewedMolecular Biology