Sivaraman Natarajan

The paper identifies non-coding somatic variants in TAL1 regulatory regions that reactivate enhancers normally active in hematopoietic stem cells in T-lineage acute lymphoblastic leukemia.

This study shows that targeting RBM39 with indisulam promotes natural killer cell activity and eradicates neuroblastoma regardless of cellular state plasticity.

Seq2Karyotype (S2K) enables in-silico karyotyping from whole-genome sequencing data, revealing intratumoral heterogeneity and evolutionary trajectories in cancer samples.

Spotiphy transforms spatial transcriptomics data into single-cell-resolved whole-transcriptome images, revealing novel cellular compositions and spatial domains in Alzheimer's and breast tissue.

This study creates two mouse models with conditional c-MYC activation in specific cell types, leading to distinct neuroendocrine tumors resembling human neuroblastoma and somatostatinoma.

This paper introduces PTA, a new WGA method that improves variant calling accuracy in single cells, enabling studies of genetic diversity and CRISPR off-target effects.

The paper identifies TCF4 and ID3 as key transcription factors driving mammary epithelial stem cell differentiation through single-cell RNA sequencing analysis.