This study identifies ZNF281 as a driver of metastatic prostate cancer and shows that targeting it with a novel inhibitor suppresses tumor growth and metastasis in multiple models.

DOI 10.64898/2026.09.03.749302

humanproteomics

𝕏 PostBluesky

Cell BiologybioRxivPreprintJan 9, 2026

An inducer of snail hibernation causes quiescence and hibernation-like cardioprotection, through metabolic rewiring and autophagy, in mice hearts

Jiyuan Piao, Yongneng Zhang, Yuanyuan Zhao…·Evangelos D. Michelakis

This study identifies a hibernation-inducing factor from snails, SNAP, which induces quiescence and cardioprotection in mice hearts through metabolic rewiring and autophagy during ischemia-reperfusion injury.

DOI 10.64898/2026.01.08.698452

mouseATAC-seq

𝕏 PostBluesky

Cancer BiologybioRxivPreprintJan 20, 2025

Hyperacute Response Proteins (HARPs) synthesized on γ-tubulin-FTO-MARK4 translation microdomains upon exposure to stress, regulate stressresponse in cancer.

Bruno Saleme, Saymon Tejay, Paul Dembele Kleouforo…·Evangelos D. Michelakis

The paper identifies stress-responsive proteins (HARPs) synthesized on γ-tubulin-FTO-MARK4 translation microdomains in cancer cells, showing their role in stress resistance and potential as therapeutic targets.

DOI 10.1101/2025.01.20.633998

humanproteomics

𝕏 PostBluesky