Separable functions of the PHD finger protein Spp1 in the Set1 and the meiotic DSB forming complexes cooperate for meiotic DSB formation.
Céline Adam, Raphaël Guérois, Anna Citarella, Laura Verardi, Florine Adolphe, Claire Béneut, Vérane Sommermeyer, Claire Ramus, Jérôme Govin, Yohann Couté, Valérie Borde
This paper identifies three separable functions of Spp1 in meiotic DSB formation, showing it interacts with Set1 and Mer2 complexes to promote recombination initiation.
PLoS Genetics · Feb 14, 2018Peer-reviewedMolecular Biology