Céline Adam

HEIP1 orchestrates pro-crossover protein activity during mammalian meiosis

This study identifies HEIP1 as a master regulator of crossover formation in mouse meiosis by orchestrating the recruitment of pro-crossover proteins.

RPA directly stimulates Mer3/HFM1 helicase processivity to ensure normal crossover formation in meiosis

This study identifies RPA as a direct interactor of Mer3/HFM1 helicase, showing its role in enhancing helicase processivity and crossover formation during meiosis.

The Pif1 helicase is actively inhibited during meiotic recombination which restrains gene conversion tract length

The paper shows that the Pif1 helicase is inhibited by the Mer3-MutLβ complex during meiotic recombination, limiting gene conversion tract length.

Mechanism of in vivo activation of the MutLγ-Exo1 complex for meiotic crossover formation

The paper identifies the role of the MutLγ-Exo1 complex in meiotic crossover formation by showing Exo1 recruits Cdc5 to activate MutLγ and highlights its spatial regulation near DSB hotspots.

Separable functions of the PHD finger protein Spp1 in the Set1 and the meiotic DSB forming complexes cooperate for meiotic DSB formation.

This paper identifies three separable functions of Spp1 in meiotic DSB formation, showing it interacts with Set1 and Mer2 complexes to promote recombination initiation.