Delphine Pflieger

This study optimizes a TMA derivatization protocol for histone PTM analysis, identifies Kacme as a novel modification, and reveals its distinct metabolic dynamics.

The paper identifies L- and D-lactylation on histones H3 and H4 in mouse testis using proteomics and shows site-specific enantiomer preferences.

The paper identifies challenges in validating isobaric histone peptidoforms using mass spectrometry and proposes strategies to improve their identification.

The paper identifies DNA methylation subtypes from transcriptomes to guide sunitinib and immunotherapy selection in renal cancer, finding hyper-methylated tumors respond better to atezolizumab plus bevacizumab.

The paper identifies key predictors of PD-1 blockade response in renal cell carcinoma by analyzing the tumor microenvironment of metastatic sites and developing a predictive TID score.

This study shows that DOT1L regulates chromatin reorganization and gene expression in male germ cells, leading to fertility defects in its absence.