Author

Hao Wu

Yale UniversityORCID 0000-0002-8903-4658Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Hao Wu23 papers · University of Pennsylvania

Biology Disciplines

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Neuroscience· 2 Bioinformatics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Approach:deep learning· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:spatial transcriptomics· 2 Research Focus:clustering· 1

Frequent Co-Authors

Alex C. KwaniD· 1 shared Alexa R. SoaresiD· 1 shared Alexander M. SherwoodiD· 1 shared Alfred P. KayeiD· 1 shared Christopher PittengeriD· 1 shared Clara LiaoiD· 1 shared Faisal MahmoodiD· 1 shared Hongyu ZhaoiD· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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1 shared paperNeuroscience

Alex C. KwanORCID

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4 papers

Recent·Most cited

SCAPE: An AI-Driven Platform for Comprehensive Single-Cell Data Analysis

Mingke Wu, Hao Wu, Yihan Zhou, Siyuan Cheng

SCAPE provides an AI-driven platform for comprehensive single-cell data analysis, demonstrating its utility in lung cancer progression studies.

bioRxiv · Nov 15, 2025 · PreprintCancer Biology

spEMO: Leveraging Multi-Modal Foundation Models for Analyzing Spatial Multi-Omic and Histopathology Data

Tianyu Liu, Tinglin Huang, Tong Ding, Hao Wu, Peter Humphrey, Sudhir Perincheri, Kurt Schalper, Rex Ying, Hua Xu, James Zou, Faisal Mahmood, Hongyu Zhao

spEMO integrates histopathology and spatial multi-omic data using foundation models, improving performance in spatial analysis and medical report generation.

bioRxiv · Jan 13, 2025 · PreprintBioinformatics

5-MeO-DMT modifies innate behaviors and promotes structural neural plasticity in mice

Sarah J. Jefferson, Ian Gregg, Mark Dibbs, Clara Liao, Hao Wu, Pasha A. Davoudian, Samuel C. Woodburn, Patrick H. Wehrle, Jeffrey S. Sprouse, Alexander M. Sherwood, Alfred P. Kaye, Christopher Pittenger, Alex C. Kwan

This study investigates the behavioral and neural effects of 5-MeO-DMT in mice, showing dose-dependent changes in behavior and long-term dendritic spine density increases without affecting spine size.

Neuropsychopharmacology · Apr 4, 2023Peer-reviewedNeuroscience

ACh signaling modulates activity of the GABAergic signaling network in the basolateral amygdala and behavior in stress-relevant paradigms.

Yann S. Mineur, Tenna N. Mose, Kathrine Lefoli Maibom, Steven T. Pittenger, Alexa R. Soares, Hao Wu, Seth R. Taylor, Yaqing Huang, Marina R. Picciotto

This study shows that acetylcholine modulates GABAergic signaling in the basolateral amygdala, altering the balance of inhibitory neuron subtypes and affecting stress-related behaviors.

Molecular Psychiatry · Sep 1, 2022Peer-reviewedNeuroscience