Dhana Friedrich

This study uses biophysical models to show that transcription factors can act as activators, repressors, or both, with their effects influenced by binding affinity and regulatory context.

This study uses mCherry-titin mice to visualize sarcomere dynamics during skeletal muscle development and injury repair, revealing titin mobility and localization patterns in myocytes.

The paper integrates modeling and synthetic biology to show that transcriptional synergy depends on both kinetic regulation of the transcription cycle and TF binding.

The paper investigates how p53-mediated transcriptional responses to DNA damage are modulated by stochastic bursting frequency, identifying distinct gene expression archetypes.