Author

Patrick S. Doyle

Beth Israel Deaconess Medical CenterORCID 0000-0003-2147-9172Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Assay:imaging· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:dimensionality reduction· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Alice L. B. PyneiD· 1 shared Barbara Sardella· 1 shared Bradley DigginesiD· 1 shared Daniel E. RollinsiD· 1 shared David JouiD· 1 shared Elizabeth P. HolmesiD· 1 shared Frank John SlackiD· 1 shared Gerburg M. WulfiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperBiophysics

Alice L. B. PyneORCID

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2 papers

Recent·Most cited

MicroRNA spatial profiling for assessing drug efficacy in BRCA1-related triple-negative breast tumors

Omar N. Mohd, Lin Wang, Barbara Sardella, David Jou, Gerburg M. Wulf, Frank John Slack, Yujing Jan Heng, Patrick S. Doyle

Latent Dirichlet allocation topics from hydrogel-array spatial miRNA maps of day-10 treated K14-Cre Brca1/Trp53 mouse breast tumors separated olaparib-sensitive (miR-21-dominated) from resistant (let-7a-dominated) tumors.

bioRxiv · Jul 20, 2026 · PreprintBiochemistry✦ In-depth digest

Multiscale topological analysis of kinetoplast DNA via high-resolution AFM

Bradley Diggines, Sylvia Whittle, Indresh Yadav, Elizabeth P. Holmes, Daniel E. Rollins, Thomas E. Catley, Patrick S. Doyle, Alice L. B. Pyne

This study uses high-resolution AFM and image analysis to analyze the topology of kinetoplast DNA, revealing structural properties and changes upon digestion.

Physical Chemistry Chemical Physics · Jan 1, 2024Peer-reviewedBiophysics