Frank John Slack

Tumor suppressor-like mutations mark a dosage-constrained dependency in leukemia

The paper shows that oncogene-imposed dosage constraints can lead to mutations resembling tumor suppressor loss, which are essential in APL.

African Green Monkey Cerebrospinal Fluid miRNome Captures Conserved miRNAs Relevant to Human Neurodegenerative Disease

The paper characterizes the miRNome of African green monkey cerebrospinal fluid, identifying conserved miRNAs relevant to human neurodegenerative diseases and highlighting species-specific variations.

MicroRNA correlates of resilience to Alzheimer's disease identify candidate therapeutic targets for neuroprotection

This study identifies miRNA signatures associated with resilience to Alzheimer's disease, revealing potential therapeutic targets for neuroprotection.

MicroRNA spatial profiling for assessing drug efficacy in BRCA1-related triple-negative breast tumors

Latent Dirichlet allocation topics from hydrogel-array spatial miRNA maps of day-10 treated K14-Cre Brca1/Trp53 mouse breast tumors separated olaparib-sensitive (miR-21-dominated) from resistant (let-7a-dominated) tumors.

miR-425-5p Regulates Cellular Senescence Through Modulation of Retinoblastoma Protein Phosphorylation

This study identifies miR-425 as a regulator of cellular senescence through modulation of RB phosphorylation and PPP2CB expression, with implications for therapeutic interventions.

A microRNA atlas of the human prefrontal cortex across the adult lifespan

The paper creates a miRNA atlas of the human prefrontal cortex across aging, identifying age-related miRNA changes and highlighting miR-34a-5p as a key upregulated miRNA in older individuals.

Aging-related Transcriptomic Changes with Spatial Resolution in the Human Prefrontal Cortex

The paper performs spatial transcriptomics on the human prefrontal cortex across the lifespan to identify aging-related changes in different cortical layers.

miR-21: A therapeutic target for delaying severe liver disease and hepatocellular carcinoma in high-fat-diet-fed mice

This study shows that reducing miR-21 levels worsens liver disease and cancer in high-fat-diet-fed mice, while miR-21 mimics improve disease outcomes.

tRNA modifications are required for stress granule formation and melanoma metastasis

This study shows that tRNA modification mcm5s2U34 is essential for stress granule formation and melanoma metastasis, suggesting it as a therapeutic target.

Host microRNA-31-5p represses oncogenic herpesvirus lytic reactivation by restricting the RNA-binding protein KHDRBS3-mediated viral gene expression

The paper identifies miR-31-5p as a regulator of KSHV lytic reactivation by targeting KHDRBS3, reducing viral gene expression and infectious virion production.

Drug resistant pancreatic cancer cells exhibit altered biophysical interactions with stromal fibroblasts in imaging studies of 3D co-culture models

This study investigates how drug-resistant pancreatic cancer cells alter biophysical interactions with stromal fibroblasts in 3D co-culture models using imaging and RNA-seq analysis.

PanomiR: A systems biology framework for analysis of multi-pathway targeting by miRNAs

PanomiR identifies miRNAs regulating groups of interacting pathways by analyzing pathway activity and miRNA-mRNA interactions in gene expression data.

Genome-wide CRISPR interference screen identifies long non-coding RNA loci required for differentiation and pluripotency

The paper uses CRISPR interference to identify lncRNA loci critical for differentiation and pluripotency in human embryonic stem cells.