Author

Sharadha Sakthikumar

Broad InstituteORCID 0000-0002-7746-8264Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Assay:whole-genome sequencing· 4 Approach:experimental assay· 2 Research Focus:GWAS / association mapping· 2 Organism:human· 2 Research Focus:clustering· 1 Research Focus:differential expression· 1 Organism:fungi (other)· 1

Frequent Co-Authors

Chao WangiD· 2 shared Christina A. CuomoiD· 2 shared Elinor K. KarlssoniD· 2 shared Guus BakkereniD· 2 shared Jeremy JohnsoniD· 2 shared John P. FellersiD· 2 shared Kerstin Lindblad‐TohiD· 2 shared Aaron L. SarveriD· 1 shared

Activity by Year

2016-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersGenomics

Chao WangORCID

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Author profile →

5 papers

Recent·Most cited

Title: Leveraging Base Pair Mammalian Constraint to Understand Genetic Variation and Human Disease

Patrick F. Sullivan, Jennifer R. S. Meadows, Steven Gazal, BaDoi N. Phan, Xue Li, Diane P. Genereux, Michael X. Dong, Matteo Bianchi, Gregory Andrews, Sharadha Sakthikumar, Jessika Nordin, Ananya Roy, Matthew J. Christmas, Voichita D. Marinescu, Chao Wang, , Arcadi Navarro

The paper uses evolutionary constraint scores to identify functional genomic regions and finds they are enriched for variants associated with common diseases.

Science · Apr 27, 2023Peer-reviewedGenomics

Whole-genome sequencing of multiple isolates of Puccinia triticina reveals asexual lineages evolving by recurrent mutations.

John P. Fellers, Sharadha Sakthikumar, Fei He, Katie McRell, Guus Bakkeren, Christina A. Cuomo, JAMES A. KOLMER

The paper analyzes whole-genome sequences of 121 Puccinia triticina isolates to study lineage evolution and mutation patterns in asexual lineages.

G3 Genes Genomes Genetics · Jul 8, 2021Peer-reviewedGenomics

Genomic analysis reveals shared genes and pathways in human and canine angiosarcoma

Kate Megquier, Jason Turner-Maier, Ross Swofford, Jong Hyuk Kim, Aaron L. Sarver, Chao Wang, Sharadha Sakthikumar, Jeremy Johnson, Michele Koltookian, Mitzi Lewellen, Milcah C. Scott, Ashley J. Schulte, Luke B. Borst, Noriko Tonomura, Jessica Alföldi, , Kerstin Lindblad‐Toh

The paper compares genomic features of canine and human angiosarcoma, finding shared genes and pathways, suggesting dogs as a valuable model for studying this cancer.

Molecular Cancer Research · Sep 30, 2019Peer-reviewedGenomics

Population Genomics Of Cryptococcus neoformans var. grubii Reveals New Biogeographic Relationships And Finely Maps Hybridization

Johanna L. Rhodes, Christopher A. Desjardins, Sean M. Sykes, Mathew A. Beale, Mathieu Vanhove, Sharadha Sakthikumar, Yuan Chen, Sharvari Gujja, Sakina Saif, Anuradha Chowdhary, Daniel John Lawson, Vinícius Ponzio, Arnaldo Lopes Colombo, Wieland Meyer, David M. Engelthaler, , Christina A. Cuomo

This study analyzes the population genomics of Cryptococcus neoformans var. grubii, revealing hybridization, biogeographic relationships, and genetic structure across global isolates.

Genetics · Jul 5, 2017Peer-reviewedGenomics

Comparative analysis highlights variable genome content of wheat rusts and divergence of the mating loci.

Christina A Cuomo, Guus Bakkeren, Hala Badr Khalil, Vinay Panwar, David Joly, Rob Linning, Sharadha Sakthikumar, Xiao Song, Xian Adiconis, Lin Fan, Jonathan M Goldberg, Joshua Z Levin, Sarah Young, Qiandong Zeng, Yehoshua Anikster, , John P. Fellers

The paper compares the genomes of three wheat rust pathogens to identify gene content variation and divergence in mating loci, highlighting differences in genome size, heterozygosity, and effector expression.

bioRxiv · Jun 24, 2016Microbiology