TOMM40-APOE chimera linking Alzheimer's highest risk genes: a new pathway for mitochondria regulation and APOE4 pathogenesis
Jinglei Xu, Jingqi Duan, Zhiqiang Cai, Chie Arai, Chao Di, Christopher C. Venters, Jian Xu, Maura Jones, Byung Ran So, Gideon Dreyfuss
The paper identifies a TOMM40-APOE chimera (T9A2) that links APOE4 to mitochondrial dysfunction and oxidative stress, suggesting a new pathway in Alzheimer's disease pathogenesis.
bioRxiv · Oct 9, 2024 · PreprintCell Biology