Cell BiologybioRxivPreprint
TOMM40-APOE chimera linking Alzheimer's highest risk genes: a new pathway for mitochondria regulation and APOE4 pathogenesis
Jinglei Xu, Jingqi Duan, Zhiqiang Cai…·Gideon Dreyfuss
The paper identifies a TOMM40-APOE chimera (T9A2) that links APOE4 to mitochondrial dysfunction and oxidative stress, suggesting a new pathway in Alzheimer's disease pathogenesis.
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