NeuroscienceJournal of Biological ChemistryPeer-reviewed
Discovery of Small Molecules and a Druggable Groove That Regulate DNA Binding and Release of the AP1 Transcription Factor DeltaFOSB
Sean McNeme, Yun Young Yim, Ashwani Kumar…·Gabby Rudenko
The paper identifies a druggable groove on DeltaFOSB that allows small molecules to modulate its DNA binding and release, with one compound reducing genomic occupancy by 60% in vivo.