Davide Michieletto

This study investigates NANOG's rheological properties, showing it forms self-limiting micelles that modulate DNA dynamics and may regulate gene expression through gel-like environments.

This study shows that topo II binding kinetics oppositely regulate decatenation and relaxation activities through a trade-off between search efficiency and processivity.

This study investigates how yeast condensin affects the rheology and viscoelasticity of entangled DNA, showing it increases viscosity and elasticity even without ATP.

This paper shows that RNA and SAF-A form a microgel network in the nucleus near the sol-gel transition, exhibiting viscoelastic properties and reconciling solid-like and fluid-like behaviors.

SuperStructure identifies complex protein structures in SMLM data without prior assumptions or parameters.

This paper uses magnetic polymer models to study how epigenetic marks and 3D genome organization interact, showing that epigenetic switches stabilize micro-phase separated compartments in the nucleus.

This study combines transcription factor and loop extrusion models to show cohesin acts as a molecular slip-link, not an active motor, in chromosome folding.

This study shows that chromatin stiffness and proximity of cohesin and CTCF sites enhance diffusive loop extrusion efficiency.

The paper uses simulations to show that dynamic protein-DNA interactions drive the formation of nuclear bodies and chromatin domains through non-equilibrium processes.

The paper introduces a polymer model with epigenetic recolouring to simulate chromatin domain establishment and 3D organization, showing phase transitions and glassy behavior under certain conditions.

This paper introduces a mesoscopic model for simulating double-stranded DNA at single-nucleotide resolution, capable of handling large DNA molecules and comparing results with experimental data.