C. A. Brackley

A model for quorum-sensing mediated stochastic biofilm nucleation

The paper presents a model showing how quorum sensing triggers stochastic biofilm formation through a transition between a loose bacterial layer and a growing biofilm.

Different factors control long-term versus short-term outcomes for bacterial colonisation of a urinary catheter

This study develops a mathematical model to show that long-term and short-term urinary catheter colonization are controlled by different factors, suggesting tailored management strategies for infection prevention.

Condensin reorganizes centromeric chromatin during mitotic entry into a bipartite structure stabilized by cohesin

This study shows vertebrate centromeres form a bipartite structure during mitosis, stabilized by condensin and linked by cohesin, which prevents merotelic attachments and chromosomal instability.

Transcription modulates chromatin dynamics and locus configuration sampling

The paper uses simulations and experiments to show transcription affects chromatin dynamics and locus configurations in mouse cells.

Complex small-world regulatory networks emerge from the 3D organisation of the human genome

This study shows that 3D genome organization leads to complex small-world regulatory networks and stochastic transcription, explaining how GWAS results align with overexpression experiments.

Lamina and Heterochromatin Direct Chromosome Organisation in Senescence and Progeria

This study uses polymer physics simulations to show that lamina and heterochromatin interactions drive nuclear organization in senescence and progeria through phase transitions.

Nucleosome positions alone determine micro-domains in yeast chromosomes.

The paper uses nucleosome positioning data to predict chromatin 3-D structure in yeast, showing that nucleosome positions alone can accurately determine micro-domain patterns observed experimentally.

Complementary chromosome folding by transcription factors and cohesin

This study combines transcription factor and loop extrusion models to show cohesin acts as a molecular slip-link, not an active motor, in chromosome folding.

Effect of chromatin flexibility on diffusive loop extrusion via molecular slip-links

This study shows that chromatin stiffness and proximity of cohesin and CTCF sites enhance diffusive loop extrusion efficiency.

Non-equilibrium chromosome looping via molecular slip-links

This paper introduces a model for chromatin loop formation through diffusive sliding of molecular slip-links, showing it can explain experimental biases without requiring motor activity.