Haruhisa Inoue

This paper presents a novel monkey model with impaired DISC1 gene to study adolescent prodromal phenotypes of psychiatric disorders, finding altered social behavior and disrupted brain connectivity.

This paper introduces ChemGLaM, a chemical genomics language model for reliable and explainable compound-protein interaction predictions, achieving state-of-the-art performance and enabling drug/target exploration for ALS.

The paper identifies non-linear gene sets from blood cells to classify ALS with high accuracy using machine learning and validates findings in lab samples and iPSC-derived motor neurons.

This study compares Cas9 and Prime Editing (PE) in human iPS cells, showing PE's superior precision and demonstrating how sorting by PE expression affects allelic editing outcomes.

This study shows that dipeptide repeat proteins from C9ORF72 mutations disrupt GEM body formation and cause SMN protein mislocalization in motor neurons.