Author

Scarlett J. Barker

Denali Therapeutics (United States)ORCID 0000-0003-2237-1569Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:non-human primate· 1

Frequent Co-Authors

Alexander StergioulisiD· 1 shared Alfred E. ChappelliD· 1 shared Allisa J. Clemens· 1 shared Anthony A. EstradaiD· 1 shared Audrey LeeiD· 1 shared Cathal S. MahoniD· 1 shared Chaeyoung KimiD· 1 shared Chrissa A. DwyeriD· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperNeuroscience

Alexander StergioulisORCID

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintApr 25, 2023

Targeting Transferrin Receptor to Transport Antisense Oligonucleotides Across the Blood-Brain Barrier

Scarlett J. Barker, Mai B. Thayer, Chaeyoung Kim…·Sarah L. DeVos

This paper demonstrates that systemically delivered OTV, a TfR-binding molecule, effectively transports ASO across the BBB, achieving widespread and sustained knockdown of target genes in the CNS of mice and non-human primates.

21 citations

mousenon-human primate

𝕏 PostBluesky

NeurosciencebioRxivPreprintMay 12, 2020

A cyclin-dependent kinase 5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes

Jinsoo Seo, Ping‐Chieh Pao, Oleg Kritskiy…·Li‐Huei Tsai

The paper identifies a Cdk5-derived peptide that inhibits Cdk5/p25 activity and reduces neurodegenerative phenotypes in cellular and animal models.

4 citations

humanmouse

𝕏 PostBluesky