Ping‐Chieh Pao

This study shows that p53 activation via DNA damage response causes aberrant neuronal activity in neurodegenerative diseases, and inhibiting p53 reduces this activity in a human iPSC model.

This study integrates multi-omics data from Drosophila and human Alzheimer's disease models to identify pathways involved in neurodegeneration.

The paper shows that combining CSF1R inhibition with GENUS stimulation improves cognitive function in Alzheimer's mice by restoring neural circuitry and gene expression.

This study identifies ABCA7 loss-of-function variants' impact on phosphatidylcholine metabolism in human neurons and shows CDP-choline can reverse these effects.

The paper uses phosphoproteomics to identify Siglec-F and Siglec-8 as upregulated in microglia during neurodegeneration, driving inflammatory responses in mouse and human models.

The paper identifies a Cdk5-derived peptide that inhibits Cdk5/p25 activity and reduces neurodegenerative phenotypes in cellular and animal models.

The paper identifies gene expression signatures in human and mouse brains linked to Alzheimer's disease and finds species-specific and shared patterns across neurodegenerative models.