Audrey Lee

This study shows that p53 activation via DNA damage response causes aberrant neuronal activity in neurodegenerative diseases, and inhibiting p53 reduces this activity in a human iPSC model.

This study investigates how P2RY12 loss affects microglial metabolic and activation states, revealing altered metabolic pathways and increased susceptibility to ferroptosis.

The paper identifies Ankyrins as critical for synaptic connectivity between horizontal cells and photoreceptors in the mouse retina through single-cell RNA sequencing and functional analysis.

The paper identifies that DNA double strand breaks in neurons activate immune pathways, leading to microglia activation in neurodegeneration.

The paper identifies a Cdk5-derived peptide that inhibits Cdk5/p25 activity and reduces neurodegenerative phenotypes in cellular and animal models.

The paper investigates the role of STR expansions in SLE using genomic data and computational tools, finding no large STR expansions in 76 SLE-associated genes.