Author

Quentin Le Grand

Université de BordeauxORCID 0000-0002-9299-0747Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:GWAS summary statistics· 1 Organism:mouse· 1 Assay:spatial transcriptomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Stéphanie DebetteiD· 2 shared Andrew F. TeichiD· 1 shared Ankita NarangiD· 1 shared Annie LeeiD· 1 shared Badri Narayan VardarajaniD· 1 shared Bengisu TurgutalpiD· 1 shared Çağhan KızıliD· 1 shared Carsten WerneriD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCell Biology

Stéphanie DebetteORCID

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2 papers

Recent·Most cited

APOE-ϵ4-induced Fibronectin at the blood-brain barrier is a conserved pathological mediator of disrupted astrocyte-endothelia interaction in Alzheimer's disease

Prabesh Bhattarai, Elanur Yılmaz, Elif Öykü Cakir, Hüseyin Tayran, Imdadul Haq, Dylan Murphy, Jonah Nadelmann Keller, Quentin Le Grand, Jacqueline Eschbach, Hilal Çelikkaya, Mehmet İlyas Coşacak, Hande Yüceer, Annie Lee, Verena Claudia Haage, Yiyi Ma, , Çağhan Kızıl

This paper identifies APOE-ϵ4-induced fibronectin accumulation at the blood-brain barrier as a key mediator of astrocyte-endothelial dysfunction in Alzheimer's disease, highlighting it as a potential therapeutic target.

Nature Aging · Sep 11, 2026Peer-reviewedCell Biology

Characterization of variants associated with Cerebral Small Vessel Disease identifies a functional SNV in Versican

Jae‐Ryeon Ryu, Ankita Narang, Quentin Le Grand, David‐Alexandre Trégouët, Stéphanie Debette, Sarah J. Childs

The paper identifies a functional SNV in Versican associated with Cerebral Small Vessel Disease using MPRA and validates its effect on transcriptional activity.

bioRxiv · Apr 18, 2026 · PreprintGenetics