PhysiologyAmerican Journal of Physiology-Gastrointestinal and Liver PhysiologyPeer-reviewed
Altered cellular metabolic pathway and epithelial cell maturation induced by MYO5B defects are partially reversible by LPAR5 activation
Michael Momoh, Sudiksha Rathan-Kumar, Andreanna Burman…·Izumi Kaji
This study shows that MYO5B defects disrupt lipid metabolism and mitochondrial structure in intestinal epithelial cells, and that LPAR5 activation with Compound-1 can partially reverse these defects and improve intestinal function in MVID models.
5 citations