Joseph T. Roland

This study shows that acute tuft cell ablation in mice causes malabsorption and changes in secretory and immune cell lineages in the small intestine.

The paper introduces MILWRM, a tool for detecting tissue domains in spatial-omics data, and demonstrates its application in human colonic polyps and mouse brain slices.

This study shows that MYO5B defects disrupt lipid metabolism and mitochondrial structure in intestinal epithelial cells, and that LPAR5 activation with Compound-1 can partially reverse these defects and improve intestinal function in MVID models.

This study shows vaccination generates functional progenitor tumor-specific CD8 T cells and halts liver cancer progression in a mouse model, while immune checkpoint blockade does not.

The paper identifies a novel epithelial cell type, LND, in Crohn's disease that is associated with immune dysregulation and disease activity.

GammaGateR provides a semi-automated marker gating tool for multiplexed imaging data, improving consistency and reducing manual effort while revealing biological signals.

This study maps tumor evolution and microenvironment dynamics in colorectal cancer using spatial multi-omic data, identifying key genes associated with immune exclusion and prognosis.

The paper presents a pipeline for cell segmentation and quantification in complex tissue images using machine learning and deep learning methods.

This paper quantifies slide-to-slide variation in multiplexed immunofluorescence data and introduces normalization methods to correct it, showing that dividing by slide mean and functional data registration perform best.