Xuewei Wang

Mapping Somatosensory Afferent Circuitry to Bone Identifies Neurotrophic Signals Required for Fracture Healing

The paper identifies neurotrophic signals, particularly FGF9, required for fracture healing by mapping somatosensory afferent circuitry to bone and analyzing gene expression changes in DRG neurons.

Roles of Kdm6a and Kdm6b in regulation of mammalian neural regeneration

This study investigates the roles of Kdm6a and Kdm6b in neural regeneration, finding they regulate axon regeneration and RGC survival with distinct mechanisms and identifying Klf4 as a downstream target.

Human birth tissue products as a non-opioid medicine to inhibit post-surgical pain

The paper demonstrates that human amniotic membrane products inhibit post-surgical pain in mice through CD44-dependent pathways and cytoskeleton rearrangements in nociceptive neurons.

Histone methyltransferase Ezh2 coordinates mammalian axon regeneration via epigenetic regulation of key regenerative pathways

This study shows Ezh2 promotes axon regeneration in the PNS and CNS by epigenetically regulating genes involved in regeneration and inhibitory signaling.

scRNA-sequencing reveals subtype-specific transcriptomic perturbations in DRG neurons of Pirt-EGFPf mice in neuropathic pain condition

The paper uses scRNA-seq to identify subtype-specific transcriptomic changes in DRG neurons of Pirt-EGFPf mice under neuropathic pain conditions.

Knocking out non-muscle myosin II in retinal ganglion cells promotes long-distance optic nerve regeneration

This study shows that knocking out myosin IIA/B in retinal ganglion cells promotes optic nerve regeneration, with synergistic effects when combined with Lin28 overexpression.

Meiosis related cancer-testis genes correlate with tumor aneuploidy and immune infiltration in 21 cancer types

The paper investigates the correlation between meiosis-related cancer-testis genes, tumor aneuploidy, and immune infiltration across 21 cancer types using multi-omics data.

Novel role of Lin28 signaling in regulation of mammalian PNS and CNS axon regeneration

This study identifies Lin28a and Lin28b as key regulators of axon regeneration in mammals, showing their ability to promote optic nerve regeneration through miRNA regulation and interaction with PTEN.