Author

Lijun Xu

QIMR Berghofer Medical Research InstituteORCID 0000-0001-9515-6128Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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2024-2025 · peak 2/yr

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

Alexander DobrovicORCID

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3 papers

Cancer BiologybioRxivPreprintApr 7, 2025

This study shows that DNMT1 inhibitors reduce BRCA1 promoter methylation in HGSOC, leading to BRCA1 re-expression and PARP inhibitor resistance.

2 citations

Cancer BiologybioRxivPreprintSep 23, 2024

The paper generates a homozygous BRCA1-methylated OVCAR8 cell line using CRISPR editing to study meBRCA1 stability and PARPi resistance.

1 citation

Genetic & Genomic MedicineMolecular CancerPeer-reviewedAug 5, 2024

This study identifies secondary splice-site mutations in BRCA1 that drive exon skipping and PARP inhibitor resistance in ovarian and breast cancer.

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