Viral RNA pUGylation Promotes Antiviral Immunity in C. elegans
David D. Lowe, Aditi Shukla, Scott G. Kennedy
This study shows that pUGylation of viral RNAs by RDE-3 in C. elegans promotes antiviral immunity by enabling RdRP-based siRNA production.
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Harvard UniversityORCID 0000-0003-2322-3437Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
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David D. Lowe, Aditi Shukla, Scott G. Kennedy
This study shows that pUGylation of viral RNAs by RDE-3 in C. elegans promotes antiviral immunity by enabling RdRP-based siRNA production.
Cindy Y. Chang, Daniel J. Pagano, David D. Lowe, Scott G. Kennedy
The paper identifies a DNA repair strategy in C. elegans somatic cells that significantly increases transposon mobilization rates compared to germline cells.
David D. Lowe, Denise J. Montell
This study identifies and characterizes the role of EIF2A in Drosophila spermatogenesis, showing its essential function in male fertility through genetic mutations.