Jennifer Davis

This study shows that the E525K β-myosin mutation reduces cardiomyocyte contraction without altering crossbridge cycling, through structural and computational analysis.

The paper uses molecular dynamics simulations to show how conformational changes in loop 2 of myosin affect actomyosin association strength through electrostatic interactions.

This paper uses a Conditional Variational Autoencoder to predict muscle twitch parameters from simulated and experimental data, identifying therapeutic targets for a cardiac mutation.

This study shows that YAP overactivation in HCM mutant cardiomyocytes drives hypertrophy via CCN2 secretion and TGFβ uptake.

The paper identifies the Foxa2 lineage's role in lung development and demonstrates that conditional complementation of this lineage can generate a whole lung in mice.