YAP dysregulation triggers hypertrophy by CCN2 secretion and TGFβ uptake in human pluripotent stem cell-derived cardiomyocytes
Orlando Chirikian, Mohamed A. Faynus, Markus W. Merk, Zachary Singh, Christopher Muray, J. Pham, Alex Chialastri, Alison Schroer Vander Roest, Alex J. Goldstein, Trevor Pyle, Kerry V. Lane, Brock Roberts, Jacqueline E. Smith, Ruwanthi N. Gunawardane, Nathan J. Sniadecki, , Beth L. Pruitt
This study shows that YAP overactivation in HCM mutant cardiomyocytes drives hypertrophy via CCN2 secretion and TGFβ uptake.
bioRxiv · Jun 3, 2024 · PreprintCell Biology