Author
University of WashingtonORCID 0000-0001-6960-4492Unclaimed ORCID profile · follow to get notified of new preprints
6 papers
Recent·Most cited
Kalen Z. Robeson, Timothy S. McMillen, Kristina Bezold Kooiker…·Michael Regnier
This study shows that the E525K β-myosin mutation reduces cardiomyocyte contraction without altering crossbridge cycling, through structural and computational analysis.
Jamison M. Whitten, Amanda J. Haack, Liam A. Knudsen…·Erwin Berthier
The paper introduces STEAM, a microfluidic platform for creating suspended tissue constructs with spatial patterning and mechanical manipulation capabilities, demonstrating its use in engineered muscle tissue.
Amanda J. Haack, Lauren G. Brown, Alex J. Goldstein…·Ashleigh B. Theberge
The paper introduces STOMP, a method to create multi-regional suspended tissues for studying complex tissue interfaces, and reports altered contractile dynamics in engineered heart tissues and bone-ligament constructs.
Orlando Chirikian, Mohamed A. Faynus, Markus W. Merk…·Beth L. Pruitt
This study shows that YAP overactivation in HCM mutant cardiomyocytes drives hypertrophy via CCN2 secretion and TGFβ uptake.
Alexander M. Loiben, Wei‐Ming Chien, Clayton E. Friedman…·Kai‐Chun Yang
This study shows that MYH7 E848G mutation causes cardiomyocyte apoptosis and contractile dysfunction in a stem cell model of HCM, independent of p53.
Alessandro Bertero, Paul Fields, Alec S.T. Smith…·Charles E. Murry
The paper investigates how lamin A/C haploinsufficiency affects chromatin compartments and gene expression in human cardiomyocytes, finding limited compartmental changes despite electrophysiological and gene expression alterations.