Smadar Shilo

The paper develops a mathematical model and formula (HOMA-C) to quantify beta cell carrying capacity in prediabetes, showing significant variation and its association with diabetes risk.

The paper estimates the heritability of metformin's glycaemic response using EHR data and population pedigrees, finding a heritability of 10.5-12.2%.

This study shows environmental factors have a greater impact on human gut microbiota than host genetics, with microbiome data adding significant predictive value to phenotypes.