Author

Iris N. Kalka

Weizmann Institute of ScienceORCID 0000-0001-9375-2946Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:benchmarking· 2 Assay:electronic health records· 1 Research Focus:GWAS / association mapping· 1 Approach:matrix factorization· 1 Assay:metagenomics· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Eran SegaliD· 2 shared Omer WeissbrodiD· 2 shared Smadar ShiloiD· 2 shared Adina WeinbergeriD· 1 shared Alexander KurilshikoviD· 1 shared Alexandra ZhernakovaiD· 1 shared Amir Gavrieli· 1 shared Anastasia GodnevaiD· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Eran SegalORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Estimating Heritability of Glycaemic Response to Metformin using Nationwide Electronic Health Records and Population-Sized Pedigree

Iris N. Kalka, Amir Gavrieli, Smadar Shilo, Hagai Rossman, Nitzan Shalom Artzi, Nancy‐Sarah Yacovzada, Eran Segal

The paper estimates the heritability of metformin's glycaemic response using EHR data and population pedigrees, finding a heritability of 10.5-12.2%.

Communications Medicine · Dec 1, 2021Peer-reviewedGenetic & Genomic Medicine

Estimating variance components in population scale family trees

Tal Shor, Iris N. Kalka, Dan Geiger, Yaniv Erlich, Omer Weissbrod

The paper introduces Sci-LMM, a framework for analyzing population-scale family trees, and estimates heritability of longevity and reproductive fitness in a large historical pedigree.

PLoS Genetics · May 9, 2019Peer-reviewedGenetics

Environmental factors dominate over host genetics in shaping human gut microbiota composition

Daphna Rothschild, Omer Weissbrod, Elad Barkan, Alexander Kurilshikov, Tal Korem, David Zeevi, Paul Igor Costea, Anastasia Godneva, Iris N. Kalka, Noam Bar, Smadar Shilo, Dar Lador, Arnau Vich Vila, Niv Zmora, Meirav Pevsner‐Fischer, , Eran Segal

This study shows environmental factors have a greater impact on human gut microbiota than host genetics, with microbiome data adding significant predictive value to phenotypes.

Nature · Feb 28, 2018Peer-reviewedGenetics