Elizabeth J. Grayhack

The paper investigates the molecular mechanisms of inhibition caused by the Leu-Pro CUC-CCG codon pair in yeast, identifying roles for tRNA competition, ribosome collisions, and TOR pathway regulation.

The paper shows that 40S ribosomal subunits scan mRNA via one-dimensional diffusion rather than helicase-driven translocation in yeast.

The paper identifies eEF3 as a promoter and Gcn1/Gcn20 as suppressors of frameshifting at collided ribosomes in yeast, showing their distinct roles in quality control mechanisms.

The paper shows that Mbf1, Rps3, and Asc1 prevent frameshifting in stalled eukaryotic ribosomes, unlike bacteria, by maintaining the reading frame through distinct mechanisms.