Author

Julia Busselaar

Leiden University Medical CenterORCID 0000-0003-2402-4245Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Douwe M. T. BosmaiD· 2 shared Jannie G. BorstiD· 2 shared Mo D. StaaliD· 2 shared Xin LeiiD· 2 shared Yanling XiaoiD· 2 shared Fiamma SalernoiD· 1 shared Mirna ReljićiD· 1 shared Mylène de KoningiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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2 shared papersImmunology

Douwe M. T. BosmaORCID

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2 papers

Recent·Most cited

ImmunologyCell ReportsPeer-reviewedApr 21, 2026

Requirements for development of T-helper1 and T-follicular helper cells from a common precursor

Douwe M. T. Bosma, Julia Busselaar, Mo D. Staal…·Fiamma Salerno

The paper shows that Th1 and Tfh cells originate from a common precursor and differentiate based on interactions with cDC1s or B cells.

1 citation

mouseexperimental assay

ImmunologyJournal for ImmunoTherapy of CancerPeer-reviewedApr 1, 2026

Stem-like PD-1+TCF-1+ CD8+ T cells result from helpless priming and rely on CD4+ T-cell help to complete their cytotoxic effector differentiation

Julia Busselaar, Douwe M. T. Bosma, Mo D. Staal…·Jannie G. Borst

This study shows that PD-1+TCF-1+ stem-like CD8+ T cells require CD4+ T-cell help to differentiate into effector cytotoxic T cells, but tumors fail to provide this help despite expressing helper epitopes.

2 citationstop 5%

mousebulk RNA-seq