Author

Jannie G. Borst

Leiden University Medical CenterORCID 0000-0002-8043-5009Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1 Approach:statistical model· 1

Frequent Co-Authors

Douwe M. T. BosmaiD· 2 shared Julia BusselaariD· 2 shared Mo D. StaaliD· 2 shared Xin LeiiD· 2 shared Yanling XiaoiD· 2 shared Bram van den BroekiD· 1 shared Eliza Mari Kwesi‐MaliepaardiD· 1 shared Elselien FrijlinkiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersImmunology

Douwe M. T. BosmaORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Requirements for development of T-helper1 and T-follicular helper cells from a common precursor

Douwe M. T. Bosma, Julia Busselaar, Mo D. Staal, Mylène de Koning, Mirna Reljić, Xin Lei, Tom de Wit, Yanling Xiao, Jannie G. Borst, Fiamma Salerno

The paper shows that Th1 and Tfh cells originate from a common precursor and differentiate based on interactions with cDC1s or B cells.

Cell Reports · Apr 21, 2026Peer-reviewedImmunology

Stem-like PD-1+TCF-1+ CD8+ T cells result from helpless priming and rely on CD4+ T-cell help to complete their cytotoxic effector differentiation

Julia Busselaar, Douwe M. T. Bosma, Mo D. Staal, Xin Lei, Yanling Xiao, Jannie G. Borst

This study shows that PD-1+TCF-1+ stem-like CD8+ T cells require CD4+ T-cell help to differentiate into effector cytotoxic T cells, but tumors fail to provide this help despite expressing helper epitopes.

Journal for ImmunoTherapy of Cancer · Apr 1, 2026Peer-reviewedImmunology

Histone methyltransferase DOT1L maintains identity and restricts cytotoxic potential of CD8 T cells

Muddassir Malik, Willem-Jan de Leeuw, Muhammad Assad Aslam, Eliza Mari Kwesi‐Maliepaard, Teun van den Brand, Bram van den Broek, Maxime Kempers, Liesbeth Hoekman, Natalie Proost, Tibor van Welsem, Nikolina Bąbała, Elselien Frijlink, Elzo de Wit, Jannie G. Borst, Heinz Jacobs, Fred van Leeuwen

This study shows that DOT1L maintains CD8 T cell identity and restricts their cytotoxic potential by preventing NK-cell features and enhancing anti-tumor reactivity.

Science Advances · Dec 12, 2025Peer-reviewedImmunology