Yanling Xiao

This paper identifies P2RY2 as a purinergic immune checkpoint that mediates eATP-driven immune evasion and adaptive resistance to immunotherapy by promoting PGE2 accumulation in the tumor microenvironment.

The paper shows that Th1 and Tfh cells originate from a common precursor and differentiate based on interactions with cDC1s or B cells.

This study shows that PD-1+TCF-1+ stem-like CD8+ T cells require CD4+ T-cell help to differentiate into effector cytotoxic T cells, but tumors fail to provide this help despite expressing helper epitopes.